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If you’ve heard of ketamine, it’s probably for its history of abuse as a club drug. But it could also be one of the biggest breakthroughs in treating severe depression in years.
How can one drug hold such promise and peril? The answer lies in how it affects your brain.
Ketamine works like a flash mob, temporarily taking over a certain chemical “receptor.” In some cases and with expert medical care, that can be a good thing. But cross that line, and it’s big trouble.
Your doctor probably won’t give it to you as an antidepressant yet. Scientists are still testing it for that. But if ketamine does bring people back from the depths of depression, it might be the last thing you expect from a drug that can knock you out.
Putting Out Pain
Ketamine got its start as an anesthesia medicine in the 1960s. It was used on the battlefields of the Vietnam War.
At lower doses, it can help ease pain. Ketamine helps sedatives work and may help people need fewer addictive painkillers, like morphine after surgery or while caring for burns.
When misused, ketamine can change your sense of sight and sound. You can have hallucinations and feel out of touch with your surroundings — and even from yourself. It can make it hard to speak or move, and it’s been abused as a date-rape drug.
“Outside of the clinic, ketamine can cause tragedies, but in the right hands, it is a miracle,” says John Abenstein, MD, president of the American Society of Anesthesiologists.
New Life as an Antidepressant?
Turning around severe depression may not literally be a miracle. But if it happens to you, it can feel like one.
Researchers are studying whether ketamine can help treat severe depression, such as in people who have tried other treatments or who are in the hospital and possibly suicidal.
The FDA hasn’t approved it for that use. But some psychiatrists are trying ketamine experimentally with their patients who have this type of depression, says John Krystal, MD, chief of psychiatry at Yale-New Haven Hospital.
What is tramadol?
Tramadol is a narcotic-like pain reliever.
Tramadol is used to treat moderate to severe pain in adults.
The extended-release form of tramadol is for around-the-clock treatment of pain. The extended-release form of tramadol is not for use on an as-needed basis for pain.
You should not take tramadol if you are allergic to it, or if you have:
severe asthma or breathing problems;
stomach or bowel obstruction (including paralytic ileus);
if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or
if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine).
Tramadol should not be given to a child younger than 12 years old. Ultram ER should not be given to anyone younger than 18 years old.
Do not give this medicine to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.
Avoid giving this medicine to children between 12 to 18 years of age who have conditions that may cause breathing problems.